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The list of the top ten best-selling games in 2010 in the U.S. offers little in the way of surprises, given that every item on the list is part of one explosively popular franchise or another, but here it is anyway for the curious:
| Rank | Title | System | Publisher |
| 01. | Call of Duty: Black Ops | PS3, 360, PC, Wii DS | Activision Blizzard |
| 02. | Madden NFL 11 | PS3, 360, Wii, PSP, PS2 | Electronic Arts |
| 03. | Halo: Reach | 360 | Microsoft |
| 04. | New Super Mario Bros. Wii | Wii | Nintendo |
| 05. | Red Dead Redemption | PS3, 360 | Take Two |
| 06. | Wii Fit Plus | Wii | Nintendo |
| 07. | Just Dance 2 | Wii | Ubisoft |
| 08. | Call of Duty: Modern Warfare 2 | PS3, 360, PC | Activision Blizzard |
| 09. | Assassin’s Creed: Brotherhood | PS3, 360 | Ubisoft |
| 10. | NBA 2K11 | PS3, 360, Wii, PSP, PS2 | Take Two |
Total consumer spend on physical game-related content in the U.S., which includes portable, console and PC game software, generated revenues of $10.1 billion, a 5% decline over the $10.6 billion generated in 2009, according to the NPD Group.
However, 2010 also saw increased spending on on used games, full-game digital downloads and downloadable content, mobile gaming apps, and social network gaming.
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