After you get access to Gion in chapter 4 of Like a Dragon: Ishin, you can kick off a The Sexy Madam substory by talking with a woman in an elaborate kimono. She’s standing right after you walk into the district after crossing the Shijo Bridge in front of Kitchen Aoba. However, if you did some basic shopping early on in Fushimi, you probably already own what she needs.
The Sexy Madam in Like a Dragon: Ishin says that she wants a cucumber. While she specifies that she wants Ryoma Sakamoto’s cucumber, any one you can find will do. The Fushimi Green Grocer sells cucumbers among the other produce for 100 mon. If you pick one up, that will work to complete the substory. (If it is your first Green Grocer purchase, you’ll also get a number of other items for free, like tomatoes.)
You will then get a Vitality Pill for bringing her a cucumber, as well as 150 Virtue. This also starts a bond relationship with her. You can also stop by later to increase the bond with her in the Diligence Records.
Like a Dragon: Ishin is available on the PS4, PS5, Xbox One, Xbox Series X, and PC.