By Spencer . October 27, 2010 . 4:02pm
Tetsuya Nomura posted a longer answer on Twitter. While the past two Parasite Eve games had the mitochondria incident as a core story element, this game doesn’t have a connection to the mitochondria mutated crocodiles. Nomura asks fans to think of protagonist Aya Brea’s story as the core of the series.
Other than Aya, The 3rd Birthday has other familiar elements like the setting (it’s still in New York) and her twin sister Maya who makes an appearance in the PSP game.