Zone of the Enders HD Collection bundles Zone of the Enders and Zone of the Enders 2nd Runner together. Actually, make that Zone of the Enders 2nd Runner Special Edition.
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Producer Hideo Kojima took a photo of the title screen confirming HD Edition will include 2nd Runner Special Edition, which will be new content for North America.
Zone of the Enders 2nd Runner Special Edition has extra cutscenes, more difficulty modes, and additional missions to play.