A.N.N.E. is a platformer-cum-shoot-em-up that’s a mix of Cave Story with elements of Mega Man. The title is in development for PC and Wii U (and eventually other platforms), and Nintendo have released a trailer for it at E3.
Siliconera got to go hands-on with A.N.N.E. at E3 last year, and we liked it quite a bit. You can read our hands-on impressions of the title in this post.