Boss fights in Naruto Shippuden: Ultimate Ninja Storm 2 deviate from regular fights, sometimes in a big way like the battle between Four-Tails Naruto and Orochimaru. From these screenshots, it appears developer CyberConnect2 added an on-rails fight where you blast Orochimaru with chakra spheres.
Sasuke has his own story mode in Naruto Shippuden: Ultimate Ninja Storm 2 and one of his major fights is against Itachi.
Here’s a look at a bunch of other characters in the game like Karin, Hinata, Tsuande, and Killer Bee. Naruto Shippuden: Ultimate Ninja Storm 2 is less than a week away with a October 19 release date in North America.