Nintendo got one E3 announcement out of the way early. They just confirmed Pokémon Black Version and Pokémon White Version for North America.
Pokémon Black and White have a new storyline, region, and, of course, new legendary Pokémon to catch. Look for both games, Zekrom, and Reshiram in spring 2011.
Legendary Pokémon Zekrom from Pokémon White Version
Legendary Pokémon Reshiram from Pokémon Black Version