Level 5 is not giving up on releasing the Professor Layton games overseas. During a GDC panel Akihiro Hino, President of Level 5, mentioned the second game in the series will come out here under the name Professor Layton and the Diabolical Box (thanks for the tip David!!). Hino hopes it will be ready in six months.
The wait for the next Professor Layton game has been a long one, but Level 5 has been working on a ton of high profile projects. White Knight Chronicles (the international version), Dragon Quest IX, Inazuma Eleven, and a new Layton trilogy are just some of the games they are working on. Also, the Professor Layton series can’t be easy to localize since the puzzles and answers can’t be directly translated. Some of them have to be adapted to make sense as brain teasers, others have to be scrapped entirely.