Resident Evil 6 has an unlockable ability that lets you play the game without the help of your partner, I learned today. You can unlock this using Skill Points.
Your partner will still be present in the game, and they’ll help you open doors and the like, but if you get pinned down, for instance, you’ll have to get up on your own.
The full extent and effects of the Lone Wolf ability is unknown so far. For instance, I couldn’t get confirmation from Marketing Coordinator, Mike Lunn, on whether or not zombies would attack your partner.
However, Lunn did say that Lone Wolf was just one of the quirky abilities you could unlock with Skill points.